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《医学前沿(英文)》 2017年 第11卷 第2期 页码 223-228 doi: 10.1007/s11684-017-0517-8
The objective of this study is to guide a triage for the management of cervical high-grade squamous intraepithelial lesion (HSIL) patients with positive margin by conization. Clinico-pathological data of HSIL patients with positive margin by conization were retrospectively collected from January 2009 to December 2014. All patients underwent secondary conization or hysterectomy within 6 months. The rate of residual lesion was calculated, and the factors associated with residual lesion were analyzed by univariate and multivariate analyses. Among a total of 119 patients, 56 (47.06%) patients presented residual HSIL in their subsequent surgical specimens, including 4 cases of invasive cervical carcinoma (3 stage IA1 and 1 stage IA2 patients). Univariate analysis showed that patient age>35 years (P=0.005), menopausal period>5 years (P=0.0035), and multiple-quadrant involvement (P=0.001) were significantly correlated with residual disease; however, multivariate analysis revealed that multiple-quadrant involvement (P=0.001; OR, 3.701; 95%CI, 1.496–9.154) was an independent risk factor for residual disease. Nearly half of HSIL patients with positive margin by conization were disease-free in subsequent surgical specimens, and those with multiple positive margins may consider re-conization or re-assessment.
关键词: cervical high-grade squamous intraepithelial lesion conization positive surgical margin hysterectomy
Clinical significance of human papilloma virus infection in the cervical lesions
Shuang LI, Yu-Han MENG, Hu TING, Jian SHEN, Ding MA
《医学前沿(英文)》 2010年 第4卷 第3期 页码 264-270 doi: 10.1007/s11684-010-0094-6
关键词: cervical lesion high risk-human papilloma virus persistent infection loading dose cervical intraepithelial neoplasia cervical cancer
Epidemiological studies of women under age 30 infected with human papillomavirus
Zhihua LIU MD, Qing LI BM, Weihong LI BM,
《医学前沿(英文)》 2009年 第3卷 第4期 页码 459-462 doi: 10.1007/s11684-009-0084-8
关键词: cervical cancer human papilloma virus cervical intraepithelial neoplasia
《医学前沿(英文)》 2023年 第17卷 第1期 页码 75-84 doi: 10.1007/s11684-022-0950-1
关键词: drug-coated balloon left main high bleeding risk predilatation calcifield lesion percutaneous coronary intervention
Molecular alterations and clinical relevance in esophageal squamous cell carcinoma
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《医学前沿(英文)》 2013年 第7卷 第4期 页码 401-410 doi: 10.1007/s11684-013-0286-y
Esophageal squamous cell carcinoma (ESCC) is one of the most common types of gastrointestinal cancers, and the fourth leading cause of cancer-related deaths in China. Early detection and intervention in time may dramatically increase the survival of the patients by initiating treatment regimens during earlier stages of ESCC or even during precancerous stages. Molecular classification will be useful for subtyping esophageal tumors or precancerous lesions to improve current therapeutics or early intervention of the disease. In this review, we summarize the findings in investigating the molecular alterations and clinical relevance of ESCC.
关键词: esophageal squamous cell carcinoma (ESCC) early detection molecular classification molecular markers
李鹤林,吉玲康,田伟
《中国工程科学》 2010年 第12卷 第5期 页码 84-90
近年来,我国管道企业和相关科研院所联合攻关,取得了一批关键技术成果,这些成果包括:研制了X70,X80钢级高性能管线钢及焊管、管件;突破国际上螺旋缝埋弧焊管的使用禁区,确立了具有中国特色的“大口径高压输送主干线螺旋埋弧焊管与直缝埋弧焊管联合使用”的技术路线;在国内首次研究了高压输气管道动态断裂与止裂问题,采用Battelle双曲线模型预测了西气东输和西气东输二线等管道延性断裂的止裂韧性;在国内首次研究了油气管道基于应变的设计方法,解决了该设计方法及抗大变形管线钢管在强震区和活动断层管段应用的技术难题;解决了高强度焊管的腐蚀控制和应变时效控制等技术。
Repurposed benzydamine targeting CDK2 suppresses the growth of esophageal squamous cell carcinoma
《医学前沿(英文)》 2023年 第17卷 第2期 页码 290-303 doi: 10.1007/s11684-022-0956-8
关键词: benzydamine cyclin-dependent kinase 2 patient-derived xenograft esophageal squamous cell carcinoma
PD-1/PD-L1 blockade in cervical cancer: current studies and perspectives
Yumeng Wang, Guiling Li
《医学前沿(英文)》 2019年 第13卷 第4期 页码 438-450 doi: 10.1007/s11684-018-0674-4
关键词: PD-1 PD-L1 immune checkpoint blockade antibody immunotherapy cervical cancer
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《医学前沿(英文)》 2017年 第11卷 第4期 页码 590-594 doi: 10.1007/s11684-017-0537-4
Grading of Recommendations Assessment, Development, and Evaluation (GRADE) offers a worldwide approach to guideline development for clinical practice. For the clinical practice of acupuncture therapy, 18 evidence-based guidelines have been developed in China using GRADE. In this study, we review the advantages and limitations of the GRADE approach in the guideline development for acupuncture and moxibustion and propose some solutions to these limitations. Scientific advantages of rating the quality of evidence, outcome-centric direction, overall progression to develop recommendations, and strength of recommendations providing specific clinical guidance are the advantages of GRADE. The limitations of GRADE in the development of guidelines for acupuncture and moxibustion include rating the quality of evidence for ancient literature and literature on famous traditional Chinese medicine experts’ experiences and specific guidelines for formulating recommendations from evidence. In the guideline development for clinical practice with acupuncture and moxibustion, we suggest that a specific method should be explored based on the GRADE approach and the characteristics of acupuncture therapy.
关键词: guideline acupuncture GRADE
Relative expression of PTTG and bFGF in oral squamous cell carcinoma and Tca8113
Yumei DING BM , Lili CHEN MD , Bo CHENG PhD , Handong ZHANG MM ,
《医学前沿(英文)》 2009年 第3卷 第3期 页码 357-362 doi: 10.1007/s11684-009-0046-1
关键词: carcinoma squamous cell pituitary tumor transforming gene (PTTG) protein basic fibroblast growth factor
Genomic variations in the counterpart normal controls of lung squamous cell carcinomas
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《医学前沿(英文)》 2018年 第12卷 第3期 页码 280-288 doi: 10.1007/s11684-017-0580-1
Lung squamous cell carcinoma (LUSC) causes approximately 400 000 deaths each year worldwide. The occurrence of LUSC is attributed to exposure to cigarette smoke, which induces the development of numerous genomic abnormalities. However, few studies have investigated the genomic variations that occur only in normal tissues that have been similarly exposed to tobacco smoke as tumor tissues. In this study, we sequenced the whole genomes of three normal lung tissue samples and their paired adjacent squamous cell carcinomas. We then called genomic variations specific to the normal lung tissues through filtering the genomic sequence of the normal lung tissues against that of the paired tumors, the reference human genome, the dbSNP138 common germline variants, and the variations derived from sequencing artifacts. To expand these observations, the whole exome sequences of 478 counterpart normal controls (CNCs) and paired LUSCs of The Cancer Genome Atlas (TCGA) dataset were analyzed. Sixteen genomic variations were called in the three normal lung tissues. These variations were confirmed by Sanger capillary sequencing. A mean of 0.5661 exonic variations/Mb and 7.7887 altered genes per sample were identified in the CNC genome sequences of TCGA. In these CNCs, C:G→T:A transitions, which are the genomic signatures of tobacco carcinogen N-methyl-N-nitro-N-nitrosoguanidine, were the predominant nucleotide changes. Twenty five genes in CNCs had a variation rate that exceeded 2%, including ARSD (18.62%), MUC4 (8.79%), and RBMX (7.11%). CNC variations in CTAGE5 and USP17L7 were associated with the poor prognosis of patients with LUSC. Our results uncovered previously unreported genomic variations in CNCs, rather than LUSCs, that may be involved in the development of LUSC.
关键词: lung cancer counterpart normal control genomic variations
A new thinprep cytologic test of cervical cells and its application
Xiaojun ZHAO, Jingjuan WEI, Rong WANG, Yajun GU, Yunde LIU
《医学前沿(英文)》 2009年 第3卷 第2期 页码 227-229 doi: 10.1007/s11684-009-0035-4
关键词: thinprep cytologic test cervical cells Papanicolaou smear
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《医学前沿(英文)》 2014年 第8卷 第1期 页码 106-112 doi: 10.1007/s11684-014-0307-5
Cervical carcinoma is associated with high propensity for local invasion and lymph node metastasis. However, the molecular alterations that drive progression and metastasis of cervical cancer remain unclear. Cellular senescence has been proposed as the mechanism that protects an organism against cancer progression and metastasis. In addition, Twist, a basic helix-loop-helix transcription factor, has been suggested as an oncogene because it is overexpressed in many types of human cancer. This gene also exhibits a positive function in regulating invasion and metastasis. In this study, Twist was strongly and positively expressed in normal tissue, squamous cell carcinoma (SCC) IA--IIA, and SCC IIB--IIIB (4.3%, 44%, and 88.9%, respectively). The strong positive expressions of the senescence marker CBX3 were 39.1%, 32%, and 15.6%, respectively. The strong positive expressions of Twist in the SCC groups with or without lymph node metastasis were 80.8% and 50%. For CBX3, such expressions were 7.7% and 29.5%, respectively. Results also showed that the expression of Twist was inversely correlated with that of CBX3. Moreover, the knockdown of Twist with target siRNA in SiHa triggered the induction of the chromatin marker of the cellular senescence CBX3 and senescence-associated β-galactosidase activity. Our results suggested that the expression of Twist increased during the progression and metastasis of cervical cancer. Furthermore, Twist-induced senescence bypass is important in this process.
关键词: cervical cancer senescence Twist CBX3 lymph node metastasis
Development of combined transitional pavement structure for urban tram track-road grade crossings
《结构与土木工程前沿(英文)》 页码 1199-1210 doi: 10.1007/s11709-023-0949-y
关键词: urban tram track grade crossing combined track-road transitional pavement polyurethane elastic concrete finite element method
Guocheng LIU MD, Shouhua YANG MD, Zehua WANG MD,
《医学前沿(英文)》 2009年 第3卷 第4期 页码 447-451 doi: 10.1007/s11684-009-0082-x
关键词: cervical cancer lymphatic vessel density blood vessel density platelet-derived growth factor
标题 作者 时间 类型 操作
Triage for management of cervical high-grade squamous intraepithelial lesion patients with positive margin
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期刊论文
Clinical significance of human papilloma virus infection in the cervical lesions
Shuang LI, Yu-Han MENG, Hu TING, Jian SHEN, Ding MA
期刊论文
Epidemiological studies of women under age 30 infected with human papillomavirus
Zhihua LIU MD, Qing LI BM, Weihong LI BM,
期刊论文
percutaneous coronary intervention of left main coronary artery disease: the importance of proper lesion
期刊论文
Repurposed benzydamine targeting CDK2 suppresses the growth of esophageal squamous cell carcinoma
期刊论文
PD-1/PD-L1 blockade in cervical cancer: current studies and perspectives
Yumeng Wang, Guiling Li
期刊论文
Application of Grading of Recommendations Assessment, Development, and Evaluation (GRADE) to the guideline
null
期刊论文
Relative expression of PTTG and bFGF in oral squamous cell carcinoma and Tca8113
Yumei DING BM , Lili CHEN MD , Bo CHENG PhD , Handong ZHANG MM ,
期刊论文
A new thinprep cytologic test of cervical cells and its application
Xiaojun ZHAO, Jingjuan WEI, Rong WANG, Yajun GU, Yunde LIU
期刊论文
Correlation of Twist upregulation and senescence bypass during the progression and metastasis of cervical
null
期刊论文
Development of combined transitional pavement structure for urban tram track-road grade crossings
期刊论文